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Platelet-Rich Fibrin


Perhaps you have already heard of platelet-rich plasma (PRP) treatments, which feature the use of blood plasma high in growth factor content to rejuvenate, restore, and rehabilitate isolated areas of the body. Platelet-rich fibrin (PRF) is much the same in that it contains high concentrations of white blood cells, fibrin, and stem cells that are naturally found circulating in the bloodstream. The difference? PRF is deemed the “second-generation” of PRP and offers more powerful anti-aging properties.


As PRF has a higher volume of stem cells than PRP, it takes on a gel-like consistency within a timeframe of about 15 to 20 minutes after separation. Thus, when injected below the skin, it can act as either an enhancer to another dermal filler or a natural filler in and of itself.

But PRF also does so much more. While its volumizing effects are not permanent, it does serve other, more long-lasting purposes:

  • Enhanced collagen production
  • Skin tightening
  • Improved skin tone and texture
  • Erasure of fine lines and wrinkles


  • Under eyes for crepey skin, puffy eyes and dark circles
  • Fines lines and wrinkles
  • Scar Treatment
  • Hair Restoration


PRF, while, similar to PRP, does feature some key differences, including the following:

  • PRP is applied topically while PRF is applied beneath the skin
  • PRP has immediate effects whereas PRF’s effects manifest later and last longer
  • PRF has a higher count of both stem cells and growth factors
  • PRF can be used in combination with PRP and/or other treatments

Frequently Asked Questions

What Is Involved In A PRF Treatment?

As with PRP, PRF is harvested by drawing your blood, placing it in a centrifuge, and separating it from the other blood components. Once isolated, the PRF is injected beneath the desired area, acting as a temporary volumizer and releasing its growth factors to aid in your overall skin rejuvenation.

How Does PRF Work?

Once injected, PRF releases its growth factors gradually over time, making for a long-lasting and more powerful effect, even though the results are not always immediately noticeable.

How Long Will The Effects Last?

PRF treatments, as with many other filler treatments, require multiple appointments spaced approximately six to eight weeks apart. The volumizing effects will typically last for the first three to four weeks before receding, and the long-term rejuvenation results will show after six weeks. The long-term effects will then last six to 12 months.

What Area Is PRF Usually Used For?

Currently, PRF is primarily used for under-eye hollows and areas in the face that have seen an overall thinning of the skin or decrease in volume.